COVID - 19
ACE2: SARS-CoV-2 Spike Compound Screening Bioassay
- Evaluation of test compounds able to interfere with the binding of the SARS-CoV-2 Spike protein with its target, the ACE2 protein exposed on the host cell surface.
- Identification of potential compounds that will contrast SARS-CoV-2 infection
Sequential incubation is performed in 96-well plate according to test samples as:
- ACE2 protein immobilisation
- Test compound pre-incubation
- SARS-CoV-2 Spike protein incubation
- Add anti-tag-HRP
- Initiate reaction with HRP substrate
- Detect chemiluminescence
Ideal compound candidates will contrast the binding of SARS-CoV-2 Spike with ACE2
Assay Principle
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